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The Food and Drug Administration has approved Novo Nordisks pill version of its Wegovy medication, a first for GLP-1 weight loss drugs

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Andr-Lvigne D, Pignel R, Boet S, Jaquet V, Kalbermatten DF, Madduri S

Importantly, GLP-1R activation in CNS regions associated with motivation and reinforcement suggests a mechanistic bridge between gut-derived metabolic signals and neuropsychiatric regulation, a foundational concept for understanding its emerging role in substance use disorders