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Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J

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Encapsulation in polymeric nanoparticles enhances the enzymatic stability and the permeability of the GLP-1 Analog, Liraglutide, across a culture model of intestinal permeability

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Semaglutide dose-dependently reduced liver enzymes, and resulted in greater NASH resolution (reduced ballooning and lobular inflammation) without worsening of fibrosis, as compared with placebo after 72 weeks of treatment