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They typically contain prebiotic fiber (resistant starch, Fibersol), probiotics ( Akkermansia muciniphila , Bifidobacterium strains), or metabolic compounds (berberine, chromium picolinate, 5-HTP, saffron extract)

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the remainder reaches the colon and may be fermented or excreted in faeces

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Paradoxically, whilst long-term weight loss typically improves joint health and reduces osteoarthritis symptoms (as noted in NICE NG226), the transition period may be associated with adjustment-related discomfort