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Figure 5 ALC reduced cholesterol synthesis by decreasing SREBP2 levels in Huh-7 hepatocytes To elucidate the cellular mechanisms underlying ALCs cholesterol-lowering effects, ALC reduced the plasma TC in mice and decreased the hepatic SREBP2 and HMGCR levels

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Insulin resistance or prediabetes is often associated with high levels of fasting glucose (due to malfunctions in glucose processing) and triglycerides (due to increased lipid production, lipolysis, and release of free fatty acids)

The Web of Science search strategy was: AB=(children OR pediatric) AND AB=(growth hormone OR growth hormone deficiency OR growth hormone treatment OR recombinant growth hormone) AND AB=(sleep quality OR sleep pattern OR sleep duration OR sleep efficiency OR sleep satisfaction OR sleep health) AND AB=(sleep study OR questionnaires OR polysomnography) NOT AB=(syndrome) NOT AB=(review OR case report)

Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA)