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Localized glutathione synthesis would be expected to have an even more pronounced effect, and it has been suggested that non-soma areas contain more glutathione (35)

doi: 10.1111/jnc.14604 150 JhelumPSantos-NogueiraETeoWHaumontALenoelIStysPKet al

doi: 10.1016/j.redox.2018.09.019

389 In addition, a combination of CR and exercise can improve cardiac mitochondrial dynamics, decrease cardiac apoptosis, and maintain cardiac [Ca 2+ ] i homeostasis in obese insulin-resistant rats

Second, the inability to quantify central nervous system (CNS) GSH concentrations in vivo has substantially hindered therapeutic trials targeting CNS augmentation