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10.1038/mp.2013.101 27 CastejonA

ROS sources ROS are unstable oxygen-containing molecules that include radical ROS (e.g., superoxide anions [O 2 ], hydroxyl radicals [OH], peroxyl radical [ROO], alkoxyl radical [RO], carbonate radical [CO 3 ], hydroperoxyl radical [HO 2 ], nitric oxide [NO], and nitrogen dioxide [NO 2 ]) and non-radical ROS (e.g., hydrogen peroxide [H 2 O 2 ], peroxynitrite [ONOO ], hypochlorous acid [HOCl], singlet oxygen [ 1 O 2 ], ozone [O 3 ], and nitrocarbonate [ONOOCO 2 ]) [11] (Table 1)

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Interestingly, all of the genes exhibited a significant negative correlation with SLE scores (SLEDAI), suggesting the critical role of these five genes in alleviating the progression of SLE

This protective function helps prevent oxidative stress, which is linked to various chronic diseases