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Because biotinoyl-5-adenylate has a labeling range at the nanometer scale, not all hits can be assigned as direct binders, but the isASO-ID protocol may allow the illumination of changes in the ASO proximity with high sensitivity due to the largely reduced background

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And the second part of it, if we can somehow twist the molecule without changing the polarity so that way it still, the effectors are still there but somehow squeeze the peptide into small beads