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In summary, therapeutic management of secondary DM in acromegalic patients should be based on a combination of metformin and GLP1-RA, as a first therapeutic approach, in line with the latest scientific evidence, in order to take advantage of the cardioprotective effects of GLP1-RA

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3 Although several factors contributed to this rise in interest, two key developments have been particularly important: Celebrity endorsement: A number of high-profile celebrities, such as Elon Musk, have publicly credited GLP-1RA drugs with their transformative weight loss, leading to a spike in public interest in using the drugs for weight loss

At the same time, Semaglutide creates a sense of fullness by raising satiety hormones while actively diminishing the hunger-inducing hormone known as ghrelin

Peters, D