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This process enhances cytokine production, oxidative stress, and endothelial inflammation, all of which may further impair NO signaling and vascular relaxation (125, 126)
IBD patients frequently have gut dysbiosis, including a decrease in butyrate-producing bacteria (197)
Tell patients to report development of blisters or erosions
Of note, unhealthy diets high in fats and sugars, particularly processed foods consumed in Western countries, affect the gut microbiota, contributing to intestinal inflammation and fungal overgrowth [68,131]
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved for type 2 diabetes management, chronic weight management, and in the case of Wegovy, cardiovascular risk reduction in certain patients