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Pharmacological antagonist studies demonstrate that co-administration of prazosin (1 antagonist) almost completely reverses tesofensine-induced appetite suppression, while SCH23390 (D1 antagonist) produces partial reversal

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NICE TA875 confirms that gastrointestinal (gut) side effects are expected with semaglutide and recommends a gradual dose escalation to minimise discomfort

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& Herold, K