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A recent simulation analysis compared continuous GLP-1 therapy vs a staged program of GLP-1 therapy until sustained weight reduction was achieved, followed by discontinuation and a structured behavioral lifestyle intervention for weight maintenance

All other chemicals were purchased from Sigma-Aldrich, unless indicated otherwise

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Mechanism information is for education only and is not a benefit claim

ELISA assay results indicated that the levels of IL-10 and TGF- in the GLP-1RAs@NPs, GLP-1RAs@NPs-WYRGRL and MNs/GLP-1RAs@NPs-WYRGRL groups were significantly increased, especially in the MNs/GLP-1RAs@NPs-WYRGRL group compared with the RA group