Italian journal of gastroenterology and hepatology , 31 (5), 401-407
In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration
In the elderly, hypothyroidism is associated with accelerated cognitive decline and an increased risk of Alzheimer's disease, raising the possibility that impaired thyroid signaling may act as a modifiable risk factor for dementia (83)
Protein aggregation propensity is a crucial determinant of intracellular inclusion formation and quality control degradation
Any suspected side effects from these or any other medicines or research chemicals should be reported to the MHRA via the Yellow Card Scheme at yellowcard.mhra.gov.uk
(2013) Thymosin Beta-4 in Zellmigrations- und Gewebereparaturmodellen