The Endocrine Society's 2024 clinical practice guideline on pharmacological management of obesity recommended GLP-1 receptor agonists and GIP/GLP-1 receptor agonists (including tirzepatide) as first-line pharmacotherapy for adults with BMI 30, adding clinical weight to coverage arguments
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Research demonstrates that GLP-1 receptor activation improves beta-cell function, reduces hepatic fat accumulation, and lowers inflammatory markers independent of substantial weight loss
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