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Smoking also may impair the phase II metabolites, thus creating more estrogen quinone metabolites with a decreased ability to eliminate them.[ref][ref] Therefore, the combo of variants in phase I and phase II genes (genotype report below) with smoking causes a fairly large increase in the risk of cervical, breast, or prostate cancer

(1979) Hydroperoxide metabolism in mammalian organs

Sakthivel M, Geraldine P, Thomas PA

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Individuals with a known allergy to any of the components, pregnant or breastfeeding women, and those with liver disease or kidney disease should not take this medication

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