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239 Studies in various animal models 240,241,242 have provided strong evidence that enhancing or restoring SERCA2a activity improves cardiac function and prevents HF progression, making it a prime target for clinical translation

Try to drink 3 to 4 bottles of water in a day

Mair et al., 2018)

In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination

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Intermittent fasting is also effective