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The American Diabetes Association's 2024 Standards of Care recognize GLP-1 receptor agonists with proven cardiovascular benefit (including semaglutide, based on SUSTAIN-6 data showing a 26% reduction in major adverse cardiovascular events) as preferred second-line agents after metformin in patients with established atherosclerotic cardiovascular disease 19

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It is also essential for regulating desquamation (loss) and keratinisation of cells in the cornea