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for example, in MASH, the abnormal accumulation of lipotoxic species, such as ceramides and diacylglycerols (DAGs), triggers inflammatory signaling that antagonizes receptor-mediated protection (Steinberg et al., 2025)

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Fatigue often peaks in the first 24 weeks and stabilizes within 68 weeks as your metabolism adjusts

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It is important to emphasize that activation of the JAKSTAT3 pathway and the upregulation of GFAP should not be interpreted as substate-specific markers of astrocyte reactivity 139

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