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Single-target GLP-1 receptor agonists certainly work, but tirzepatides dual-action mechanism appears to create a synergistic effect

Glycolysis decreases

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This polypharmacological profile allows them to address several pathogenic processes simultaneously

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)