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GLP-1 may modulate lipid metabolism through increased sympathetic tone, leading to increased lipolysis, heightened triglyceride catabolism, and enhanced fatty acid oxidation (181)

Fatigue (often due to reduced calorie intake)

Shed started a research protocol about six weeks earlier

It is hypothesized that with continued use and continued titration of insulin, superior reductions in A1C would be seen with an intensive insulin therapy compared to GLP-1 RAs

Drug availability, indications, and insurance coverage can change over time

The result, in animal models and now in human Phase 2 and Phase 3 trials, is not an incremental 1-2 percentage point gain over tirzepatide