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The amount of deglutamylated compounds increased linearly over the 6-h incubation period

The microdose protocol emphasizes tolerance and sustainability over rapid titration

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A precursor for cellular methylation reactions, methionine plays an important role in lipid metabolism, polyamine synthesis, immune function, heavy metal chelation, and maintenance of redox balance.4Conversely, dietary methionine restriction in rodents increased energy expenditure, improved insulin resistance, and enhanced lipolysis and fatty acid oxidation in adipose tissue.[1] The lipotropic effects of methionine may be attributed to its metabolite S-adenosyl methionine (SAM)

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