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This potential new setup offers greater safety in terms of quality control, says Christopher Mendias, PhD, a rehabilitation clinician-scientist at Performance Medicine Institute in Phoenix, Arizona
Nevertheless, previous vaccine studies for SARS-CoV suggest that vaccine-induced antibodies may directly promote enhanced disease upon exposure to the virus via the activation of macrophages able to produce high levels of the chemokine CCL2 and the cytokine IL-8, resulting in lung injury 5
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EZH2-mediated epigenetic alteration of secreted frizzled-related protein 1 (SFRP1) significantly correlates with the activation of RA FLS (308)
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Ethical/regulatory aspects Given the novelty, informed consent must emphasise off-label / investigational status
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