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J Med Food (2019) 22:15261

What are the theoretical safety concerns discussed for IGF-1 signaling

Levothyroxine dosing in the elderly targets a slightly higher TSH (up to 6 to 8 mIU/L in patients over 80), which reduces overreplacement risk and thereby limits the CYP2E1-upregulation concern

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The current observational study therefore aimed to provide further real-world evidence concerning the comparative effectiveness of semaglutide OW versus SGLT2is in relation to change in weight, body mass index (BMI), HbA1c, and composite outcomes, as well as all-cause HCRU and medical costs, in patients with T2D over a 1-year period