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Observational data from STEP and SURPASS trials showed secondary improvements in quality-of-life and depression screening scores, with approximately 40% of users reporting mood enhancement after six months

Tirzepatide also activates a related GIP receptor, giving it a dual effect that often leads to greater weight reduction

01, 2022, Academic Press

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We are far away from understanding exactly why brain needs to express its own GLP-1 and how brain GLP-1, gut-produced GLP-1, as well as their receptor GLP-1R expressed in selected cell linages, orchestrate the anorectic program physiologically and patho-physiologically

For sublingual GLP-1 drops, the interaction may be less of a concern since the medication absorbs through the mouth rather than the stomach