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11-13 GLP-1 receptors are expressed in multiple tissues, therefore, GLP-1RAs have multiple mechanisms of action (Figure 2)
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Chronic stress elevates cortisol, which promotes visceral fat storage and undermines insulin sensitivity
This section will summarize clinical safety findings on semaglutide and liraglutide, including common and serious side effects, safety considerations, and important precautions
Tirzepatide (Mounjaro/Zepbound) has demonstrated greater weight loss than semaglutide in clinical trials, with participants losing up to 22.5% of body weight
It started with evidence summaries (clinical practice guidelines, UpToDate and DynaMed), followed by evidence syntheses or synopses (systematic reviews), and finally original studies (randomized controlled trials and observational studies)
