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Overall, however, in countries where universal newborn screening has rendered symptomatic PKU almost nonexistent, it is estimated that only 0.7% (62) of patients with a diagnosis of PKU will meet the criteria for ASD

Dunn WB, Broadhurst D, Begley P, et al

Individual Variation: Baseline pigmentation darkness, genetics, and sun damage history affect timeline

Obesity and overweight [Internet]

Importantly, if diarrhea persists beyond 4 weeks or worsens in intensity, you should contact your healthcare provider to rule out other causes and discuss potential adjustments to your treatment plan

Achieving intensive glycemic goals during the active treatment period of the study had a persistent beneficial impact over the 20 years after the active treatment component of the study ended (13)