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reported a study on bladder cancer cells that showed p62 promoted tumor growth by triggering the KEAP1-Nrf2 signaling pathway [86]

78,269,270 Treatment with a URAT1 inhibitor suppresses the ERK pathway and mitigates uric acid-induced cell damage, underscoring the involvement of intracellular uric acid in MAPK activity

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Abdominal visceral fat, which responds well to beta-3 adrenergic stimulation, appears particularly susceptible to the combination approach