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And, it wasnt until the 1960s and 70s that pharmacological treatments began to gain traction, particularly for opioid use disorder (OUD)

If you are low in Vitamin B12 or have a deficiency anaemia, you will not be creating enough red blood cells and the ones you do make might be defective, being abnormally large

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Unlike B12 deficiency, there is no specific treatment to reduce elevated levels, nor is this usually necessary, as high B12 is not directly toxic