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for instance, H3K18la-mediated modification upregulates pro-hypertrophic genes (e.g., ANP, BNP, and -MHC) [139], while Snail1 lactylation activates TGF-/Smad2 signaling to promote aggressive interstitial fibrosis [140]

Studies had shown that a HFD can disrupt gut microbial balance, linked to the development of atherosclerosis (Xu et al., 2022)

406,407 The AGA recommends completing surgery before discharge in mild cases

The BRD4 binding motif, VHL E3 ligase binding motif, D-(+)-biotin motif, and linker are colored red, blue, purple, and black, respectively