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Se ha identificado el gen supresor de tumores STK11 (una serina-treonina quinasa), en las etapas ms tempranas del desarrollo de hamartomas y adenocarcinomas en este sndrome28, por lo que se ha enfatizado la importancia de estudiar la alteracin de este gen en pacientes con SLH, para determinar si est relacionado con el SPJ21

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CD163, a cell surface protein with high binding affinity for specific substrates, is a distinctive M2-type TAM marker