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Ammonium increases Ca 2+ signalling and upregulates expression of Ca v 1.2 gene in astrocytes in primary cultures and in the in vivo brain

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It is the main by-product (via biliverdin) from the oxidation and breakdown of the haem moiety arising from red cell destruction (80%) and other proteins, such as myoglobin and catalase (20%), in the reticuloendothelial system tissue of the spleen, bone marrow and so forth