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However, there are several common side effects that many patients report experiencing when they begin using GLP-1 medications

In the HG-induced transfection of PINK1 siRNA in HK-2 cell model and HFD/STZ induced DKD rats model induced by HFD/STZ, a novel aldose reductase inhibitor (WJ-39) was found to inhibit aldose reductase activity, activate the PINK1/Parkin signaling pathway, promote mitophagy, and alleviate cell apoptosis, thereby exerting a certain therapeutic effect on DKD and inhibiting renal fibrosis [137]

Stem Cells Dayt Ohio 34 (2), 456469

While these medications show favorable outcomes in HbA1c reduction and weight loss, cost and tolerability remain significant barriers to widespread use

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