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Another study using the long-acting GLP-1 receptor agonist dulaglutide reported sex-dependent effects on alcohol consumption, with stronger and more persistent reductions in males and different alterations in reward-related brain signaling between males and females (Vallf et al., 2020)

P21 is BBB permeable with a plasma half-life exceeding six hours, giving it sustained access to brain tissue

Hepatology 50 , 20142021