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FIGURE 1 Estrogens play a multifaceted role in the central nervous system (CNS), influencing synaptic plasticity, neuronal development, and survival in newly formed spinal synapses, as well as promoting neural stem cell proliferation and maintaining the integrity of the blood-brain barrier ( Preclinical and human studies have shown that ER is abundantly expressed in the hypothalamus, particularly in the preoptic area (POA), ventromedial nuclei (VMN), amygdala, and periventricular nuclei (PV)

For how a diffuse type of hair loss differs in principle from patterned forms, we explain it in detail in our foundational article

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Peptides occur naturally in the body, but their levels decline with age

This initial dose is to allow the body to adjust to the medication as opposed to being the therapeutic dose on which to achieve weight loss