Piperine may also interfere with efflux drug transporters and phase I cytochrome P450 enzymes and increase the bioavailability and slow the elimination of a number of drugs, including phenytoin (Dilantin), propranolol (Inderal), theophylline, and carbamazepine (Tegretol) (121-123)
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1 ( Reference Dunn and Dunn 38 , Reference Hess, Zimmermann and Arnold 39 )