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Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations

Int J Dev Neurosci

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17 These deregulations became more evident when claudin-1 TG mice were subjected to DSS-colitis and subsequent recovery resulted in persistent mucosal inflammation

For GI-local goals, oral route animal data is reasonably supportive

As mentioned before, depression can be a real problem in withdrawal and can sometimes be severe enough to pose a risk of suicide, though this is unusual with slow tapering