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Imaging studies using SPECT, PET, and ASL have shown reduced CBF in MS patients across all major subtypes, without reaching ischemic severity [271, 272]

Additional experiments confirmed that persulfides and polysulfides do not block APEX2 activity (Extended Data Fig

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For example, a study of inter-relationship between MTHFR polymorphism and MDD found that the minor T-allele of MTHFR C677T was associated with increased folate deficiency-related body mass index and homocysteine levels in MDD patients only 72

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