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Their biological effects may be inappropriate for generalized metabolic disease but highly relevant for behaviorally mediated subtypes, reinforcing the need for stratified translational strategies

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This study is not without limitations

Given that microvascular dysfunction is a hallmark of cardiovascular aging [59,60,61], our findings position endothelial IGF- 1 signaling as a potential target for preserving peripheral vascular health and muscle performance

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

The skin becomes visibly thinner, loses elasticity, and becomes prone to damage