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Incorporation of Ga(III) in place of iron disrupts the iron-dependent redox process as Ga(III) cannot be reduced to Ga(II) under physiological conditions, and thus cannot be liberated from porphyrins by haem oxygenase ( A
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Ito cells) are the principal effectors of liver fibrosis, transitioning from quiescent vitamin A-storing cells to activated myofibroblast-like cells (-SMA+