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doi: 10.1038/nchembio.209 78 FinanBYangBOttawayNSmileyDLMaTClemmensenCet al

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doi: 10.1111/dom.13129 31

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When calories are restricted or food intake changes rapidly, hormonal systems respond by increasing hunger signals and reducing metabolic efficiency

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About 10% of participants on the highest dose discontinued treatment due to their adverse events, compared to 5% of those on placebo

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