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Currently, there are ten classes of orally available pharmacological agents to treat T2DM: 1) sulfonylureas (SU), 2) meglitinides, 3) metformin (a biguanide), 4) thiazolidinediones (TZDs), 5) alpha glucosidase inhibitors, 6) dipeptidyl peptidase IV (DPP-4) inhibitors, 7) bile acid sequestrants, 8) dopamine agonists, 9) sodium-glucose transport protein 2 (SGLT2) inhibitors and 10) oral glucagon like peptide 1 (GLP-1) receptor agonists (6-8)

Step 3: Tailored treatment plan

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305,306 Despite the biodegradability and biocompatibility of PLL, its in vivo activity remains limited due to its high toxicity, low transfection efficiency, and poor endosomal escape ability

Patients with proliferative retinopathy should be referred for treatment according to standards of care established by pivotal studies such as the Diabetic Retinopathy Study, the ETDRS, and the Diabetic Retinopathy Clinical Research Network (DRCR) Protocol S ( Figure 1 )

Beano or Phazyme (simethicone) help break up gas bubbles, while ginger tea or peppermint tea support digestive comfort