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KawamotoSTranTHMaruyaMSuzukiKDoiYTsutsuiYet alThe inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut

196,197,198 The phosphorylation of Akt is necessary for its full activation, allowing it to regulate a variety of downstream effector proteins involved in cell survival, proliferation, metabolism, and glucose transport

10.3390/cells10010113 206 SiegelG.ObernostererG.FioreR.OehmenM.BickerS.ChristensenM.et al

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Odenwald MA, Turner JR (2017) The intestinal epithelial barrier: a therapeutic target

It inhibits the activation of the transcription factor NF-B, reducing the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO)