Glutathione catabolism as a signaling mechanism
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While following L-carnitine oral challenge, E4-TR mice had higher increases in the L-carnitine metabolites, GBB and crotonobetaine in the brain and a reduction of plasma to brain total acylcarnitine ratios compared to other genotypes
Hypoglycaemia risk is the primary safety consideration, along with potential joint swelling and carpal tunnel effects at higher doses
