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Its dual action makes retatrutide a useful reference point for studying downstream signaling mechanisms, such as cyclic AMP activation, and the integrated hormonal responses that govern energy expenditure and adiposity (fat accumulation)

GLP-1 medications include Ozempic (semaglutide), Victoza (liraglutide), Trulicity (dulaglutide), and others, while GLP-1/GIP medications include Mounjaro (tirzepatide)

Forbes, J

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They can also be used to prevent and treat endocrine disorders or metabolic diseases such as polycystic ovary syndrome (PCOS), obesity, and non-alcoholic fatty liver disease (NAFLD) (135)

Learn the mechanism, status, trial evidence, and limits