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Most people will feel the effects for about 1 week

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Lewis TD, Malik M, Britten J, San Pablo AM, Catherino WH

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Consistent with this, exogenous -KG supplementation can enhance Arg1 expression and suppress iNOS expression, and changes in metabolic ratios such as -KG/succinate are closely associated with the activation of M2-related transcriptional programs ( It should be noted that the effects of Gln metabolism on polarization direction are markedly context-dependent