Alongside GLP-1 is GIP (glucose-dependent insulinotropic peptide), made by K-cells higher up the intestine
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The reduction of pro-inflammatory cytokines, improvement in intestinal barrier integrity, and potential modulation of gut microbiota composition represent mechanisms that could theoretically complement existing IBD therapies
They fasted before arriving for the study, then they were given a snack bar to standardize caloric intake and stomach contents
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During the semaglutide titration phase, nausea is one of the most common reasons for discontinuation, and B6 may help reduce its intensity