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This reduction was associated with downregulated NFB expression and partial suppression of MAPK and AP-1 signaling, elucidating that GAC1 may have potential for treating TNF- mediated inflammation [110]

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Protocol overview: BPC-157 administered via subcutaneous injection, locally near the affected joint Standard dosing range: 200500 mcg per injection session Treatment duration: 48 weeks of active treatment Follow-up assessments: 6 months and 12 months post-treatment Patients were evaluated using validated pain scales (VAS and KOOS scores) and functional mobility assessments at each follow-up point

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