This means that AOD-9604: Does not raise IGF-1 , no systemic anabolic effect Does not cause insulin resistance , a frequent side effect of high doses of hGH Has no growth effect , no influence on the growth of bones, soft tissues, organs Does not cause acromegaly , because it does not act as GH It is one of the few molecules where we have managed to surgically separate one effect of GH (lipolysis) from the others
Both promote angiogenesis through different pathways, creating complementary blood vessel formation
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The soft-tissue evidence for both compounds is overwhelmingly rodent and cell-culture
B12 and Older Adults While a B12 deficiency isnt as prevalent as something like vitamin D or folate, evidence suggests that 10-15% of people over the age of 60 are low in B12, likely due to loss of a protein called intrinsic factor, which is essential for the body to absorb vitamin B12
The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo
