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However, a clinical trial utilizing nivolumab, a PD-1 inhibitor, in patients with metastatic castration-resistant prostate cancer (mCRPC) failed to demonstrate notable objective response rates (Topalian et al., 2012)

Lazarus, S.J

Agents such as vitamin C also have well-characterized beneficial effects apart from the antiviral properties we have highlighted here

10.1038/nrrheum.2013.14 Nat

How these circuits interact mechanistically has not been resolved, and ongoing studies aim to clarify whether synergy is consistently reproducible or simply model-dependent

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