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The FDA label for semaglutide includes a warning about acute pancreatitis and gallbladder disease, though the exact incidence in GLP-1 users remains lower than in rapid surgical weight loss

A 52-week study found that the most common side effects were: nausea (experienced by 40% of participants) flushing (20%) headache (12%) You also might notice that your blood pressure goes up and your heart rate goes down each time you take it

doi:10.1016/j.ntt.2021.106984 Price SAL, Nankervis A

Fontaine, R

These visits are important for helping to keep you on track with your weight loss goals and to address any challenges or obstacles you may encounter along the way

The article reports that most patients notice initial nausea or appetite suppression within 24 to 72 hours of the first dose, attributing that speed to rapid action on GLP-1 receptors in the brainstem and gut