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Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status (Organization, 2000)

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Although technically challenging, this should be further investigated, especially in light of the neuroimaging findings in ME/CFS, described in the following paragraphs

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Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement

PMID: 185 FukushimaAAizakiYSakumaK